You need to install gobject-introspection and gtk+3 using slapt-get and build pygobject3 and webkitgtk3 using slapt-src. Also, ppub would crash when I clicked on File => Open. Googling the error I found that doing the following in a terminal as root fixed the problem
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root[rich]# glib-compile-schemas /usr/share/glib-2.0/schemas